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KMID : 0644120050180010094
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Journal of Oriental Gynecology
2005 Volume.18 No. 1 p.94 ~ p.110
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Effects of Kamikwibitang on Serum Levels of Corticosterone and Histamine and Immune Response after Immobilization Stress in Mice
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Wee Seok
Lee Seung-Jun
Yoo Sim-Keun
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Abstract
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The purpose of this research was to investigate the effects of Kamikwibitang water extract (KKT) on immobilization stress in C57BL/6J mice. KKT decreased the serum level of histamine and corticosterone increased by immobilization stress. In addition, KKT decreased the cell viability of thymocytes and enhanced the cell viability of splenocytes decreased by immobilization stress. Also, KKT decreased the viability of thymocytes and splenocytes in vitro. KKT decreased DNA fragmentation of splenocytes increased by immobilization stress. KKT decreased the population of thymic CD4+CD8- cells increased by immobilization stress, and did not affect the population of B220+ cells and the population of Thy1+ cells changed by immobilization stress and enhanced the population of splenic CD4-CD8+ cells increased by immobilization stress. KKT enhanced the production of γ-interferon and did not affect the production of interleukin-2 and interleukin-4 decreased by immobilization stress. Also, KKT decreased the phagocytic activity and the level of nitric oxide decreased by immobilization stress. These results indicate that KKT may be useful for the prevention and treatment of stress via suppression of serum histamine and corticosterone level and enhancement of specific-immune response.
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KEYWORD
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Kamikwibitang (KKT), immobilization stress, thymocytes, splenocytes, immune response
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